Abstract: Given that Hesigewula South Open-pit Coal Mine is located in an alpine region with harsh natural conditions such as low temperature, drought, and wind erosion, self-developed software and the internationally commonly used Geo-slope software were applied to analyze and evaluate the slope stability of the stope and dump in Hesigewula South Open-pit Coal Mine. A slope system design scheme and a displacement acceleration graded early warning model were proposed, and an automatic early warning system was developed. The research results showed that the landslide mode in the first mining area and the trial mining area was mainly a combination of shear-through-bedding, along-bedding, and bulging, while the slope of the external dump was mainly characterized by a combination of shear-through-bedding and along-bedding, or circular sliding along the shear-weakened basement. The south side of the east slope, the east side of the south slope, the west slope in the first mining area, and the east side of the south slope of the southern external dump were all key monitoring areas. By arranging 2 radars, adding 186 GNSS monitoring points and 6 deep displacement monitoring points, full coverage of displacement monitoring for all slopes in the stope and dump has been realized, providing effective technical support for the safe production of the mine.